Many experts previously believed that strict
vegetarians were the primary group that could develop a vitamin B12
deficiency. If you had adequate stores of this important nutrient in
your body, the experts believed you were “safe” for many years from
developing a B12 deficiency.
Now we know better.
Vitamin B12 depletion and deficiency are much more common than
previously thought, especially in the over-60 population. In fact,
it’s believed that almost one in four people over 60 have deficient
levels of this vital vitamin.
Equally disturbing are emerging signs that other age groups harbor suboptimal blood levels of B12 as well.
Why is vitamin B12 deficiency such a big deal?
Your body depends on vitamin B12 for a host of functions, including…
- Helping to maintain normal energy levels*
- Promoting healthy neurological activity, including mental alertness*
- Supporting normal homocysteine levels for healthy cardiac function*
- Helping to ease occasional stress and sleeplessness*
- Maintaining healthy cell growth and repair*
- Promoting normal immune function*
- Supporting normal metabolism of carbohydrates and fats*
When your blood levels of vitamin B12 are low, one or more of these functions may be disrupted.*
Without adequate blood levels of B12, you can experience
symptoms related to low energy, mental fatigue, mood changes, sleep
difficulties, and even occasional indigestion.*
Your body relies on the efficient conversion of carbohydrates
to glucose – your body’s source of fuel – just like your car needs to
be able to use gas to run smoothly. Vitamin B12 plays a major role in
that conversion in your body.* Likewise, B12 enables your body to
convert fatty acids into energy as well.*
Contrary to what you might have heard, there’s really no solid
evidence that supplemental vitamin B12 helps you lose weight.
Overall, vitamin B12 is a nutrient your body cannot do without
for efficient, healthy metabolism of fats and carbohydrates.*
How You Get Vitamin B12 Deficient
The older you get the more likely you are to have a vitamin B12
deficiency. The two ways that you become deficient in vitamin B12 are
from not getting enough in your diet and from losing the ability to
absorb it.
I recently visited India which is primarily a vegetarian based
culture and current studies there show about 80% of the adults are
deficient in vitamin B12. However, vegans are not the only ones who can
become vitamin B12 deficient.
The older you get the more your digestive system breaks down,
especially if you have been following the standard American diet.
Specifically the lining of your stomach gradually loses its ability to
produce hydrochloric acid which releases vitamin B 12 from your food.
The use of antacids or anti ulcer drugs will also lower your stomach
acid secretion and decrease your ability to absorb vitamin B 12.
Infection with Helicobactor pylori, a common contributor to stomach
ulcers, can also result in vitamin B12 deficiency.
However the main cause of vitamin B 12 deficiency is a term
researchers call food-cobalamin malabsorption syndrome. Cobalamin is
the scientific term for vitamin B12. This typically results when
your stomach lining loses its ability to produce intrinsic factor
which is a protein that binds to vitamin B12 and allows your body to
absorb it at the end of your small intestine.
Figure 1. Cobalamin (cbl) absorption and metabolic pathway. (
A) Structure of cobalamin (vitamin B12) with a corrin ring bound to a central cobalt atom. (
B)
The metabolic journey of cbl from nutrient intake to its intestinal
absorption. Endocytic receptors and proteins responsible for vitamin
B12 intestinal absorption include cubilin (CUBN), amnionless (AMN),
receptor-associated protein (RAP) and megalin (LRP-2). The membrane
megalin/transcobalamin II (TCII) receptor complex allows the cellular
uptake of cbl. Lysosomal-mediated degradation of TCII and subsequent
release of free cbl is essential for vitamin B12 metabolic functions.
MS: methonine synthase; THF: tetrahydrofolate; MTHFR:
methyltetrahydrofolate reductase; MCM: methylmalonyl coA mutase.
NEW Form of Vitamin B12 Not Found in Most Health
Food and Vitamin Stores
If you often feel tired, run-down, and lacking in energy, you're
not alone. Low energy is one of our country's biggest health
complaints.
Some of the top reasons for this are:
- Refined foods sold in grocery stores are depleted of vital nutrients...
- Refined foods are loaded with sugar...
- Refined foods are full of chemicals...
- Refined foods are overloaded with food colorings; and...
- Refined foods are loaded with preservatives...
...but it doesn't stop there, either.
Add the harmful effects of caffeine, pollution, conventional
therapies, and the stress most of us experience everyday... and you've
got yourself a recipe for energy drain.
Well, I'm here to tell you there's a new way to give yourself
extra energy.* Actually, a cutting edge way to feel more energized --
without the jitteriness of caffeine.* More on this in a moment.
Now, of course,
powering up with extra energy is just one of B12's many health benefits*. So...
What Critical Health Benefits
Does this Vitamin Bring to the Table?
For starters, vitamin B12 helps folic acid regulate the formation of red blood cells, and helps your body use iron*.
In addition, it is also needed for proper digestion, food
absorption, carbohydrate and fat metabolism.* It also helps keep your
nervous system healthy by assisting the nerves of your body to
function and communicate in an optimal manner.*
But that's not all...far from it!
B12 also helps in cell formation and cellular longevity.* Plus,
it can support female reproductive health, and promote normal nerve
growth and development by maintaining the fatty sheaths.* These fatty
sheaths play a vital role as they cover and protect your nerve
endings.*
What's more,
this workhorse of a micronutrient is critical to your circulation and adrenal hormone production -- plus, it helps boost your immunity.* And, oh yes, let's not forget...
Vitamin B12 supports a healthy mood and feelings of well-being.*
And then there's this -- it also provides excellent support for your
memory, mental clarity, and concentration.*
Aside from using B12 to give you an energy boost, when does it
also make sense to supplement with this all-important vitamin? Well,
there are several good reasons to take vitamin B12.
And the first reason to take it is if you are a carb type or a strict vegetarian.
If You Avoid Meat, You Probably
Need to Take B12
Vegetarians have an increased need for vitamin B12 |
Many people avoid red meats for a large variety of reasons. If
you are one of them, you are at a high risk for developing vitamin B12
deficiency. Why? Because plant sources have virtually no vitamin B12.
And oral forms of B12 in nearly all supplements are
practically useless, as little is absorbed into your bloodstream.
Vegetarians should take this essential micronutrient to ensure an adequate supply of it,
because
it is found almost exclusively in animal tissues. And, the few plant
foods that are sources of B12 are actually B12 analogs -- not the form
that provides all the benefits of the real deal.
Simply put, an analog is a substance that blocks the uptake of true B12. The result being,
your body's need for the nutrient actually increases.
Furthermore, your body's need for this nutrient may also
increase if you take Metformin©. Metformin may interfere with calcium
metabolism. And this interference may reduce B12 absorption, because
this absorption requires calcium.
Studies suggest that 10% to 30% of patients taking Metformin
show evidence of reduced vitamin B12 absorption. That's why it is
important to speak with your doctor to discuss the best way to maintain
B12 levels when taking this medication.
Now, if getting a good night's sleep has also become increasingly more difficult for you, here's...
What Your Sleeping Difficulties May Be Trying to Tell You!
If you suffer from sleeping difficulties, I recommend taking
vitamin B12 during the day. I believe it can help you.* Here's why.
B12 plays a vital role in melatonin production.*
Melatonin has been called "the sleep hormone" because it is responsible for letting you get a good night's sleep.
As you age, it becomes increasingly more difficult to get a good
night's sleep because your body becomes less efficient at making this
hormone. And that's why it's a good idea to take B12 to help you sleep
like a baby each night.*
Moreover, a lack of adequate B12 can have other annoying consequences too.
Do You or a Loved One Experience Any of
the Following?
Not many know it, but if you or a family member experience:
- Tiredness and feelings of weakness...*
- Less-than-optimal nervous system functioning...*
- Less-than-optimal eye health...*
- Loss of appetite and unintended weight loss...*
- Occasional constipation and gas...*
- Feelings of mild moodiness...*
- Less-than-optimal memory...*
- A tendency toward nervousness...*
- Less-than-optimal balance...*
- Less-than-optimal liver or heart health...*
- Premature grey hair...
- Occasional digestive issues...
...
you may need to supplement with vitamin B12, even if you eat foods rich in B12. Oddly enough, that wasn't a typo.
You can eat plenty of meat, poultry, lamb's liver, brewer's
yeast, clams, eggs, herring, mackerel, kidneys, milk, dairy products, or
seafood -- and still have low levels of B12. How can that be?
It could be because your body is unable to absorb it from your
gut. You see B12 needs the help of a protein in order to be absorbed.
That protein is called
intrinsic factor.
And because the lining of your stomach makes intrinsic factor, people
with less-than-optimal gastrointestinal health often need to supplement
with B12.*
Likewise,
most people over the age of 50 have a limited ability to absorb B12, too. Thus, the need for supplementation
Pain-Free Supplementation
With that said, the form of vitamin B12 I'm recommending does NOT come as a pill, tablet, capsule, gelcap, or liquid.
Amazingly, it's B12 in a spray.
A modern marvel that I believe gives most people far better results than anything else. The name of this new product is B12 Energy Booster.* And it's only available here on Mercola.com.
Now, here's the question you may be asking at this point:
"How can something as simple as a spray
work so much better than a pill, tablet, or
capsule?"
In a nutshell, I came across an American company that uses Nano
technology. This breakthrough technology uses a patented NanoMist®
delivery system that
shrinks the size of the B12 molecule all the way down to microscopic nanodroplets™.
How does this benefit you?
Quite simply, the B12 in
B12 Energy Booster comes in an easily absorbed form your body can
now use*.
It turns out that this fine-mist spray formula you spray into
your mouth causes the essential nutrients to become absorbed rapidly.*
As a result, it
delivers more of this product's nutrients to your circulatory system, tissues and cells quickly.* And that's not all...
The tiny nanodroplets™ in each fast-acting spray are designed to
release the B12 vitamin within a steady, time-controlled manner. This
ensures a longer-term benefit from each single dose, boosting
efficiency even further.
Needless to say, when you combine
B12 Energy Booster's* time-release
mechanism with its rapid, uniform and complete absorption, you get one
incredible product. A product that, in my opinion, is clearly
superior to any B12 pill, tablet, capsule, gelcap, or liquid on the
market today.
Remember -- only a small fraction of this crucial vitamin gets
absorbed through your gut when you take it in a pill, tablet, capsule,
or gelcap.
Why Our "Nano" Products are Safe
Our manufacturer uses molecular mechanism based formulations
consisting of highly concentrated oral spray, dropper, and beverage
delivery systems in order to allow for absorption throughout the
complete digestive system and to reduce first pass liver metabolism.
They have screened over a thousand raw materials and observed
very large differences in particle size and solubility. They then
utilized a proprietary screening process to identify raw materials
that have the smallest particle size combined with natural methods to
balance the hydrophobicity (HLB/LogP) and ionic state (pKa, zeta
potential) in a water based delivery vehicle.
They have identified numerous food approved, GRAS, and natural
products to restore the solubility and bioavailability of most dietary
supplements. Their technology delivers completely natural, NOT
synthetic, molecules to your digestive system in a form that most
closely mimics the hydrated structure found in nature.
The Safe “Nano” Formulation Process
After extensive experimentation our manufacturers found that the
most effective methods to enhance the solubility of raw materials
is to use a panel of gentle natural methods to disperse (predigest)
artificial amorphous aggregates to nanoparticles or smaller (i.e.
solution, dispersion, emulsion).
They verify the small particle size by ultrafiltration and
particle size analysis using laser diffraction. Unlike the process
used in most tablets, they do not add binders, fillers, flow agents, or
other artificial excipients. A brief summary of the natural methods
used to make stabilized solutions are discussed below that vary for
each raw material used in our molecular mechanism based formulations.
- Solvent is purified water to mimic 70% found in living systems.
- Mild heat to provide kinetic energy to relax the crystalline lattice of aggregates.
- Emulsification with natural nano molecules (e.g. saponins, bile salts, phospholipids).
- Use only low energy mixing equipment that does not disrupt chemical bonds (i.e. mimic shear from chewing).
- Use natural co-solvents based on LogP and HLB of raw materials (e.g. vegetable glycerin).
- Adjust pH to for optimal ionization for solubility and to decrease microbial growth.
- Adjust ionic salts to stabilize charged molecules in solution (i.e. Zeta potential).
- Use natural preservatives such as rosemarinic acid, glycerine and potassium sorbate (low total dose in 780ul spray).
- Add natural molecules to stabilize active ingredients (e.g. prevent hydrolysis, oxidation, precipitation).
- Use standardized raw materials for highest concentration of active ingredients (HPLC standardized).
- Use great tasting all natural flavorings and essential oils for improved compliance.
- Use natural sweeteners with specific health benefits (e.g. xylitol).
Better than the FDA Requires
Our manufacturer's technology platform reverses the artificial
large amorphous aggregates to maximize absorption and provides a
preferred administration vehicle for the large number of people that do
not like to swallow tablets/capsules.
By using laser diffraction and dynamic light scattering they
found that the particle size of most dietary supplements (even those
claimed to be nano) contain particle aggregates of 1 to 100 microns
(size of bacteria to dust mites).
Particles that are micron size contain thousands of molecular
aggregates that are often larger in size than the cell and not useful
unless they can be digested. The FDA only requires vitamin
manufacturer's to show that the tablets/capsules break apart, and does
not specify any particle size requirement or that the formulation can
be processed effectively by the digestive system.
The main method the body has designed to disrupt aggregates
(i.e. chewing) is not even used with tablet/capsule formulations.
Bioavailabilty studies from a hundreds of peer reviewed publications
with drugs or natural products consistently shows that a reduction
particle size increases absorption (i.e. AOC, Cmax).